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The association between PM 2.5 exposure and neurological disorders: A systematic review and meta-analysis - PubMed

  • Paper
  • Mar 10, 2019
  • #AirPollution
Xinbiao Guo
@XinbiaoGuo
(Author)
Ken Kin Lam Yung
@KenKinLamYung
(Author)
Pengfei Fu
@PengfeiFu
(Author)
Felix Man Ho Cheung
@FelixManHoCheung
(Author)
pubmed.ncbi.nlm.nih.gov
Read on pubmed.ncbi.nlm.nih.gov
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Recent systematic review and meta-analyses have tried to identify an association between PM2.5 exposure and stroke, but few could find a conclusive and comprehensive evidence. Moreo... Show More

Recent systematic review and meta-analyses have tried to identify an association between PM2.5 exposure and stroke, but few could find a conclusive and comprehensive evidence. Moreover, the associations between PM2.5, neurodegenerative diseases and neurodevelopmental disorders have never been reviewed. We aimed to assess the effects of PM2.5 exposure on stroke, dementia, Alzheimer's disease, autism spectrum disorder (ASD), Parkinson's disease, and mild cognitive impairment (MCI).

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Patrick Collison @PatrickCollison
  • Curated in Air Pollution
A 3.26x (albeit with very wide CI) increase in Alzheimer's incidence for each 10 µg/m³ increase in long-term PM2.5 exposure? "Short- and long-term PM2.5 exposure was associated with increased risks of stroke (short-term odds ratio 1.01 [per µg/m³ increase in PM2.5 concentrations], 95% CI 1.01-1.02; long-term 1.14, 95% CI 1.08-1.21) and mortality (short-term 1.02, 95% CI 1.01-1.04; long-term 1.15, 95% CI 1.07-1.24) of stroke. Long-term PM2.5 exposure was associated with increased risks of dementia (1.16, 95% CI 1.07-1.26), Alzheimer's disease (3.26, 95% 0.84-12.74), ASD (1.68, 95% CI 1.20-2.34), and Parkinson's disease (1.34, 95% CI 1.04-1.73)." – Fu et al 2019.
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