Here's a great book (2020) by @AthenaAktipis about the evolutionary origins & nature of cancer. Might help understand the problem & guide research.

The Cheating Cell by @AthenaAktipis. Darwinian approach to evolution of cancer and cancer-resistance. Brilliant book, up there with Nesse & Williams. Tussle between opposing selection pressures means cancer is an inevitable byproduct of selection for individual advantage.